Mayank Markande came into the limelight during his debut season in the Indian Premier League with Mumbai Indians. The cricketer debuted in IPL in 2018 and in his first campaign took a total of 15 wickets. Markande made his Twenty 20 debut for Punjab in the 2017-18 Sayed Mushtaq Ali Trophy and List A debut in the 2017–18 Vijay Hazare Trophy.