Scientists Develop Novel Mechanism To Inactivate SARS-CoV-2 Virus by Blocking Their Entry to Cells & Reducing Infection Ability
The rapid emergence of new strains of the SARS-CoV-2 virus has diminished the protection offered by COVID-19 vaccines calling for new approaches to prevent infection by the virus.
Researchers have reported the design of a new class of synthetic peptides that can not only block the entry of SARS-CoV-2 virus entry into cells but also clump the virions (virus particles) together, reducing their ability to infect. This novel approach provides an alternative mechanism to render viruses like SARS-CoV-2 inactive, promising a new class of peptides as antivirals.
The rapid emergence of new strains of the SARS-CoV-2 virus has diminished the protection offered by COVID-19 vaccines calling for new approaches to prevent infection by the virus. India Reports 20,139 New COVID-19 Cases, 38 Deaths in Past 24 Hours.
It is known that protein-protein interaction is often like that of a lock and a key. This interaction can be hampered by synthetic peptide that mimics, competes with, and prevents the ‘key’ from binding to the ‘lock’, or vice versa. Scientists at the Indian Institute of Science (IISc), in collaboration with researchers from the CSIR-Institute of Microbial Technology, have exploited this approach to design peptides that can bind to and block the spike protein on the surface of SARS-CoV-2 virus. This binding was further characterised extensively by cryo-electron microscopy (cryo-EM) and other biophysical methods.
The research was supported under the COVID-19 IRPHA call of SERB Science and Engineering Research Board (SERB), a statutory body of Department of Science and Technology (DST).
(The above story first appeared on LatestLY on Jul 14, 2022 12:17 PM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website latestly.com).