Washington D.C. [USA], Jan 30 (ANI): The use of low calorie artificial or natural sweeteners by pregnant mothers leads to higher body fat levels in their offsprings, as revealed by a recent study.Such sweeteners have also been found to disrupt the gut microbiome of these children.The gut microbiome consists of microorganisms that inhabit our intestinal tract in trillions, which can influence our health and risk of numerous diseases.The findings of this study -- led by Dr. Raylene Reimer, Ph.D., which got published in the high-impact journal Gut -- are of great significance as they shed a light on the impact of low-calorie sweeteners on the critical early years of life, particularly during pregnancy and breastfeeding."Low-calorie sweeteners are considered safe to consume during pregnancy and lactation, however evidence is emerging from human studies to suggest they may increase body weight and other cardiovascular risk factors," says Reimer, a University of Calgary professor in the Faculty of Kinesiology, and Department of Biochemistry & Molecular Biology at the Cumming School of Medicine, and member of the Alberta Children's Research Institute."Even stevia, which is hailed as a natural alternative to aspartame and other low-calorie artificial sweeteners, showed a similar impact on increasing offspring obesity risk in early life."Aspartame, an artificial sweetener, and stevia, a natural low-calorie sweetener extracted from a plant native to South America, are 200-400 times sweeter than sugar. Stevia, gaining popularity, was historically used in Paraguay and Brazil to treat diabetes and is an emerging ingredient in many natural products and protein drinks.In response to higher obesity rates, the use of low-calorie sweeteners has risen, particularly in women and children. Daily consumption is associated with large babies and early menstruation in young females under 10 years - a known risk factor for chronic diseases. Additionally, the presence of some but not all of these sweeteners has been detected in breastmilk presenting a potential mode of transmission, according to the study."Understanding the impact of dietary ingredients on maternal metabolism and gut microbiota may help to define the optimal maternal diet, one which promotes a healthier future for both mother and child," says Reimer.Our understanding of how sweeteners affect weight gain is not complete but there is reason to believe that alterations in the gut microbiota may play a key role. In this animal study, a fecal transplant was used to show the direct influence of altered gut microbiota on causing the increased obesity risk. Transplanting fecal matter from the offspring of mothers that consumed the low-calorie sweeteners into sterile, germ-free mice caused the mice to gain more weight and have worse blood glucose control. Even though the offspring had never consumed the sweeteners themselves, the changes to mom's microbiota and metabolism were sufficient to change the microbiota in their offspring and trigger obesity."A healthy pregnancy, including good nutrition, is important for a healthy baby," says Reimer. "Our research will continue to examine what makes an optimal diet and more importantly seek to find ways to correct disruptions to gut microbiota should they occur." (ANI)

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