Washington, August 29: A recent study suggests athletes with a history of concussion may show more brain injury from a later concussion, particularly in middle regions of the brain that are more susceptible to damage, when compared to athletes with no history of concussion.

The research was recently published in the online issue of Neurology, the medical journal of the American Academy of Neurology. Also Read | Volcanic Eruptions Might Have Created Oxygen in Atmosphere, Say Researchers.

The athletes participated in sports like football, volleyball and soccer. "We know concussions may have long-term effects on the brain that last beyond getting a doctor's clearance to return to play," said study author Tom A. Schweizer, PhD, of St. Michael's Hospital in Toronto, Canada. Also Read | Mask Debate Moves from School Boards to Courtrooms in US Amid COVID-19 Pandemic.

He added, "It is unclear, however, to what extent the effects of a repeated concussion can be detected among young, otherwise healthy adults. We found even though there was no difference in symptoms or the amount of recovery time, athletes with a history of concussion showed subtle and chronic changes in their brains."

This study focused on changes within two areas in the middle of the brain that are especially vulnerable to concussion. Researchers focused on blood flow in the cingulate cortex and white matter microstructure in the corpus callosum.

Changes in blood flow and microstructure that show up on brain scans can indicate underlying brain injury. The cingulate cortex is a layer of grey matter that coordinates sensory and motor skills. Below it is the corpus callosum, broadband of nerve fibres linking the two hemispheres of the brain.

The study looked at 228 athletes with an average age of 20. This included 61 with a recent concussion and 167 without. Within the first group, 36 had a history of concussions. Within the second group, 73 had a history of concussions. Researchers took up to five brain scans of each recently concussed athlete, from time of injury to one year after returning to play.

Researchers found that one year after a recent concussion, athletes with a history of concussion had sharper declines in blood flow within one area of the cingulate compared to those without a history of concussions. Those with a history of concussion had an average cerebral blood flow of 40 millilitres (mL) per minute, per 100 grams (g) of brain tissue. Those without a history of concussion had an average cerebral blood flow of 53 mL per minute, per 100g of brain tissue.

In athletes with a history of concussion, in the weeks after a new concussion, researchers also found microstructural changes in a region of the brain called the splenium, which is part of the corpus callosum.

"Our findings suggest that an athlete with a history of concussion should be watched closely, as these subtle brain changes may be worsened by repeated injury," said Schweizer. "Additionally, our results should raise a concern about the cumulative effects of repeated head injuries later in life."

A limitation of the study is that athletes reported their own histories of concussions and could be inaccurate. Further research is needed that would follow athletes over time.

The study was supported by the Canadian Institutes of Health Research, the Canadian Institute for Military and Veterans Health Research and Siemens Healthineers Canada.

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